Not known Details About indazole protecting group
Substitution at R3 using a halogen or alkoxy group (74f–74i) resulted in a slight increase in mobile potency With all the halide analogs (74g–h) demonstrating best the potency during the group. Even more optimization triggered the invention of 74i–j, with 74k as quite possibly the most Lively compound from the sequence (pIC50 = six.seventy se